The motor protein Myosin 1G functions in FcγR-mediated phagocytosis
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چکیده
منابع مشابه
The motor protein myosin 1G functions in FcγR-mediated phagocytosis.
Phagocytosis is the force-dependent complex cellular process by which immune cells engulf particles. Although there has been considerable progress in understanding ligand-receptor-induced actin polymerisation in pushing the membrane around the particle, significantly less is known about how localised contractile activities regulate cup closure in coordination with the actin cytoskeleton. Herein...
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Anna E. Dart*, Sylvain Tollis, Michael D. Bright, Gad Frankel and Robert G. Endres Division of Molecular Biosciences, Imperial College, London SW7 2AZ, UK Centre for Integrative Systems Biology and Bioinformatics, Imperial College, London SW7 2AZ, UK Division of Cell and Molecular Biology, Imperial College, London SW7 2AZ, UK Centre for Molecular Microbiology and Infection, Imperial College, Lo...
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Grb2-associated binder 2 (Gab2), a member of the Dos/Gab subfamily scaffolding molecules, plays important roles in regulating the growth, differentiation, and function of many hematopoietic cell types. In this paper, we reveal a novel function of Gab2 in Fcgamma receptor (FcgammaR)-initiated phagocytosis in macrophages. Upon FcgammaR activation, Gab2 becomes tyrosyl phosphorylated and associate...
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Phagocytosis of Ab-coated pathogens is mediated through FcγRs, which activate intracellular signaling pathways to drive actin cytoskeletal rearrangements. Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-dependent processes in a variety of cell types, including those important in the adaptive immune response. Using pharmacological inhibition as well as dominant ne...
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Phagocytosis is a highly ordered process orchestrated by signalling through Rho GTPases to locally organise the actin cytoskeleton and drive particle uptake. Specific Rho family members that regulate phagocytosis are not known, as the majority of studies have relied on the use of dominant-negative mutants and/or toxins, which can inactivate multiple Rho GTPases. To identify the relevant GTPases...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2012
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.109561